Publications

Ribon Publications and Posters

Wigle TJ, Church WD, Majer CR, Swinger KK, Aybar D, Schenkel LB, Vasbinder MM, Brendes A, Beck C, Prahm M, Wegener D, Chang P, Kuntz KW. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes. SLAS Discovery (2019); doi: 10.1177/2472555219883623.

Church WD, Majer CR, Swinger KK, Aybar D, Santospago AG, Perl NR, Schenkel LB, Vasbinder MM, Kuntz KW, Wigle TJ. Development of Novel Biochemical Assays for the Screening of MonoPARP Enzymes. Society for Laboratory Automation and Screening (SLAS) 2020 International Conference and Exhibition.

Lu AZ, Abo R, Ren Y, Gui B, Mo J, Blackwell D, Wigle TJ, Keilhack H, Niepel M. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation. Biochem Phamacol (2019); 167:97-106. doi: 10.1016/j.bcp.2019.05.007.

Lu AZ, Najjar R, Niepel M, Stokes M. Novel antibody reagents for the characterization of protein ADP-ribosylation. 2018 Cold Springs Harbor Laboratory Meeting on the PARP Family and ADP-Ribosylation.

Swinger K, Wigle TJ, Wei P, Zhang S, Tong S, Chang P, Kuntz KW. Co-crystal structure of PARP16 bound to its physiological cofactor NAD+. 2018 Cold Springs Harbor Laboratory Meeting on the PARP Family and ADP-Ribosylation.


Selected Scientific References

Bock FJ, Chang P. New Directions in PARP Biology. FEBS J. (2016); doi: 10.1111/febs.13737.

Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science (2016); 353:45-50.

Vyas S, Matic I, Uchima L, Rood J, Zaha R, Hay RT, Ahel I, Chang P. Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun. (2014); 5:4426. doi: 10.1038/ncomms5426.

Vyas S, Chang P. New PARP targets for cancer therapy. Nat Rev Cancer (2014); 14:502-9. doi: 10.1038/nrc3748.

Vyas S, Chesarone-Cataldo M, Todorova T, Huang YH, Chang P. A systematic analysis of the PARP protein family identifies new functions critical for cell physiology. Nat Commun. (2013); 4:2240. doi: 10.1038/ncomms3240.

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