Our Science
Within the emerging field of stress support pathway biology, we are focusing on a set of enzymes, including PARP7 and PARP14, that utilize nicotinamide adenine dinucleotide, or NAD+, a co-substrate that is central to cellular metabolism. NAD+ regulates functions such as DNA replication and gene transcription under conditions of cellular stress.
We believe that this linkage between the intrinsic cellular stress response and the extrinsic activation of both the innate and adaptive immune systems is an attractive area for drug development.
We created our robust BEACON+ platform of technologies and chemical assets to discover novel vulnerabilities related to cellular stress support pathways and to develop small molecules inhibiting these pathways and targets.
“We believe that this linkage between the intrinsic cellular stress response and the extrinsic activation of both the innate and adaptive immune systems is an attractive area for drug development.”