Our Science

Within the emerging field of stress support pathway biology, we are focusing on a set of enzymes, including PARP7, that utilize nicotinamide adenine dinucleotide, or NAD+, a co-substrate that is central to cellular metabolism. NAD+ regulates functions such as DNA replication and gene transcription under conditions of cellular stress.

We believe that this linkage between the intrinsic cellular stress response and the extrinsic activation of both the innate and adaptive immune systems is an attractive area for cancer drug development, since cancer cells have high levels of cellular stress and modulating the immune system can lead to antitumor activity.

To identify and exploit the vulnerabilities of cancer cells to cellular stress, we created our robust BEACON+ platform of technologies and chemical assets to discover and develop small molecules inhibiting these pathways and cellular stress targets.

Inhibiting Stress Support Pathways

“We believe that this linkage between the intrinsic cellular stress response and the extrinsic activation of both the innate and adaptive immune systems is an attractive area for cancer drug development.”

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