Senior Research Associate, Biochemical & Cellular Pharmacology

Ribon Therapeutics is a biotechnology company pioneering the discovery of new cancer medicines that target monoPARP proteins, critical regulators of cancer survival mechanisms. Ribon offers a fast-paced, team-oriented work environment and a comprehensive benefits package, including health, dental, 401(k), paid vacation, and much more. Ribon is located in Cambridge, Massachusetts, which is easily accessible by car and public transportation.

Job Description

Senior Research Associate/Biochemical & Cellular Pharmacology – Determine optimal conditions for growth of mammalian cancer cell lines, and mammalian immune and neuronal cell lines. Develop novel cell-based assays from first principles using engineered cell lines, primary cells, and/or immortalized cell lines. Apply flow cytometry to characterize immune cells. Manage research at contract research organizations. Characterize protein levels and post-translational modifications using techniques such as Western blotting, ELISA, MSD, Mass Spectrometry in cells and animal tissues. Analyze gene expression using qPCR and microarrays. Prepare samples for DNA/RNA sequencing. Use confocal microscopy to assess cellular signaling and morphology. Mentor interns and co-op students. Establish techniques to detect biomarkers predictive of drug response in patients. Publish results in peer-reviewed journals. Communicate results to functional teams and matrix project teams.

Education and Requirements

Requirements include a Bachelor’s degree or equivalent in in Biology, Biomedical Sciences, Pharmaceutical Sciences or Biochemistry or related field and five years of work experience in the job offered or related field of Biochemical and Cellular Pharmacology; or, in the alternative, a Master’s degree or equivalent and three years of work experience.

If qualifying by Bachelor’s degree or equivalent, must have at least five years’ experience with mammalian cell culture and aseptic techniques. Must also have at least three years’ with the following: working with and isolating primary immune cells; cell assay development, such as viability assays, cell biophysical assays (e.g. NanoBRET), and immunofluorescence assays using high content microscopy; protein detection (Western blotting, ELISA, MSD, and Mass spectrometry); and standard molecular biology techniques (RNA/DNA extraction, and qPCR). Must have at least two years’ experience with flow cytometry and data analysis using FlowJo, and at least one year managing projects at contract research organizations.

If qualifying by Master’s degree or equivalent, must have at least three years’ experience with mammalian cell culture and aseptic techniques, as well as protein detection (Western blotting, ELISA, MSD, and Mass spectrometry). Must also have at least one-year experience with the following: working with and isolating primary immune cells; flow cytometry and data analysis using FlowJo; and managing projects at contract research organizations. Must have at least two years’ experience working with cell assay development, such as viability assays, cell biophysical assays (e.g. NanoBRET), and immunofluorescence assays using high content microscopy; as well as standard molecular biology techniques (RNA/DNA extraction, and qPCR).


If qualified, please email resume to Linette Grey ([email protected]). Please reference job code 16427 in subject line.

Join our team of experts.
Find Out More