DMPK Project Lead

Ribon is a clinical stage biopharmaceutical company pursuing the development of novel small molecules targeting stress support pathways in cancer and inflammation using our proprietary BEACON+ (Blocking the Enzyme Activity Component of NAD+) platform.

A DMPK Project Lead is responsible for representing the DMPK function on Ribon’s drug discovery project teams by providing DMPK-related guidance for the iterative drug discovery process. This role will be responsible for analyzing, synthesizing and interpreting DMPK data from hit identification to early clinical development and disseminating results in a collaborative, multidisciplinary team environment. Key deliverables are prediction of human pharmacokinetics and projection of an efficacious human dose, in addition to early DDI risk prediction. This role includes working with various CROs on the in vitro and in vivo ADME, PK, PK/PD, and TK studies to ensure timely data-driven decision making.

Primary Responsibilities:

  • Work cross-functionally and closely with various disciplines involved in Ribon’s drug discovery efforts, including biology, medicinal chemistry and drug safety to advance small molecule drugs towards clinical studies.
  • Participate in the iterative design process to build-in necessary ADME properties of small molecule drugs.
  • Effectively communicate DMPK-related data, its interpretation, and relevance to multidisciplinary project teams.
  • Apply current best practices for early prediction of human PK.
  • Assess drug-drug interaction risks early in the discovery process.
  • Managing external vendors in the conduct of in vitro/in vivo studies.
  • Presenting data, collaborative findings and plans to key stakeholders.


  • Ph.D. in pharmacokinetics, drug metabolism, or related discipline and 5+ years of pharmaceutical/biotech industry experience in DMPK (or M.S. and 10+ years) is required.
  • Ability to evaluate and progress preclinical compounds into development candidates through in vitro and in vivo ADME profiling .
  • Experience with, and in depth understanding of techniques used to predict human pharmacokinetics including in vitro scaling, allometry and PBPK modeling.
  • Understanding of DDI concepts including those involving metabolic and transporter mechanisms.
  • Experience with applying basic models to predict perpetrator and victim drug-drug interactions.
  • Experience in the oversight of outsourced DMPK studies.
  • Excellent verbal and written communication skills as well as strong interpersonal skills are essential.
  • Demonstrated success working in teams across multiple functional areas .

Other Essentials and Key Success Factors:

  • Intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit.
  • Ability to think critically in fast-paced projects with a keen sense of urgency and demonstrated ability to problem solve.
  • Self-motivated, able to direct the work of others, and contribute to a productive and collaborative team environment.
  • Highly organized and detail-oriented with a passion to deliver quality results.
  • Strong verbal and written communication skills with an ability to build relationships internally and externally.
  • Approaches their work with high levels of professionalism, integrity and personal confidence.

If you are interested in joining Ribon’s team, please email your resume to [email protected]

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