About Cellular Stress

Cellular stress responses represent a range of molecular changes a cell activates when faced with environmental and cellular stressors, including exposure to toxins, viruses, DNA damage, and proteotoxic, hypoxic, metabolic and oxidative stress. Many diseases are characterized by a dependency on cellular stress responses; for example, the cellular stress response is a hallmark of cancer.

Cancer is a complex disease characterized by genetic alterations in oncogenes and tumor suppressor genes. These alterations enable cancer cells to undergo unchecked proliferation, and as a consequence, cancer cells are subject to multiple types of cellular stress such as the accumulation of DNA damage, high levels of unfolded proteins and an inability to uptake enough nutrients needed to fuel this aggressive growth. To survive these stresses, cancer cells activate stress response pathways. Regulators of these stress response pathways provide new classes of cancer dependency targets beyond oncogenes.

At Ribon Therapeutics, we aim to block these stress response pathways by focusing on a class of proteins called monoPARPs, which are emerging as key regulators of the cellular stress response in defined cancer patients.

While the role cellular stress responses play in disease development is widely recognized, there remain unexplored families of proteins that contribute to stress-related disease development – that is where Ribon is focusing.”

Victoria Richon, Ph.D., President and CEO, Ribon Therapeutics

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